화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Korea Polymer Journal, Vol.7, No.3, 203-207, June, 1999
Export Citation
Albumin Release form Multiblock Copolymer Consisting of Poly(γ-benzyl L-glutamate) and Poly(ethylene oxide)
Chong-Su Cho†, Young-Il Jeong1, Sung-Ho Kim2, Jae-Woon Nah3, Young-Moo Lee4, Inn-Kyu Kang5, and Yong-Kiel Sung6
  • Division of Biological Resources and Materials Engineering, Seoul National University, Suwon 441-744, Korea
  • 1Department of Polymer Engineering, Chonnam National University, Kwangju 500-757, Korea
  • 2College of Pharmacy, Chosun University, Kwangju 501-759, Korea
  • 3Department of Polymer Science and Engineering, Sunchon National University, Sunchon 540-742, Korea
  • 4Department of Industrial Chemistry, Hanyang University, Seoul 133-791, Korea
  • 5Department of Polymer Science, Kyungpook National University, Taegu 702-701, Korea
  • 6Department of Chemistry, Dongguk University, Seoul 100-715, Korea
E-mail:
Biodegradable hydrogel based on moltiblock copolymer composed of poly(γ-benzyl L-glutamate)(PBLG) as the biodegradable and hydrophobic part, and poly(ethylene oxide)(PEO) as the swellable and hydrophilic part was synthesized by polymerization of γ-benzyl L-glutamate N-carboxyanhydride(BLG-NCA) initiated by bis[poly(ethylene oxide)bis(amine)] and characterized. From infrared measurement, it was found that the polypeptide block exists in the α-helical conformation, as in PBLG homopolymer. Water content of the copolymers was dependent on the PEO content in the copolymers. The amount of albumin released from the multiblock copolymers increased with an increase of PEO content in the block copolymer. Albumin was mainly released from biodegadable hydrogel through the diffusion mechanism.
  1. Heller J, Bioerodible Systems, in Medical Applications of Controlled Release, R. Langer and D.L. Wise, Eds., Boca Raton: CRC Press, vol. 2, pp. 70-80 (1984)
  2. Hsieh DST, Controlled Release Systems: Fabrication Technology, Boca Raton: CRC Press, vol. 2 (1988)
  3. Baker R, Controlled Release of Biologically Active Materials, John Wiley & Sons, New York (1987)
  4. Bialer M, Clin-Pharmacokineti, 22, 11 (1992)
  5. Mura P, Boll. Chim. Farmaceutico-Anno, 128, 326 (1989)
  6. Mura P, Pharm. Acta-Helv., 65, 298 (1990)
  7. Heller J, Ng SY, Penhale DWH, Fritzinger BK, Sanders LM, Burns RA, Gaynon MG, Bhosale SS, J. Control. Release, 6, 217 (1987) 
  8. Negishi N, Bennet DH, Cho CS, Jeong SY, Heeswijk WA, Feijen J, Kim SW, Pharm. Res., 4, 305 (1987) 
  9. Park H, Park K, Hydrogels in bioapplications, in Hydrogels and Biodegradable Polymers for Bioapplications, R.M. Ottenbrite, S.J. Huang, and K. Park, Eds., ACS Symposium Series 627: American Chemical Society, pp. 2-10 (1994)
  10. Fuller WD, Biopolymers, 15, 869 (1976)
  11. Cho CS, Kim SW, Sung YK, Kim KY, Makromol. Chem., 189, 1505 (1988) 
  12. Cho CS, Jo BW, Kwon JK, Komoto T, Macromol. Chem. Phys., 195, 2195 (1994) 
  13. Cho CS, Kim SW, Komoto T, Makromol. Chem., 191, 981 (1990) 
  14. Smith PK, Krohn RI, Hermanson GT, Anal. Biochem., 150, 76 (1985)