A well-dispersed Co-Mn catalyst immobilized on calcined Cow bone was synthesized and used, for the first time for the selective synthesis of benzophenone by liquid phase oxidation of diphenylmethane under various reaction conditions. The catalyst was characterized using techniques such as UV-vis, SEM, TEM and BET. The catalyst has shown an excellent activity (87%), selectivity to diphenyl ketone (90%) and stability under solvent free conditions. To investigate the leaching of the metals from the support, results of the original and reusable catalyst was correlated and compared, and the catalytic activity of washed catalyst was also demonstrated. Based on the all catalytic results for this reaction, the new catalyst was found to be a highly active and environmentally friendly solid catalyst and has superior catalytic activity. (C) 2013 Elsevier B.V. All rights reserved.