Ir-V nanoparticles are prepared with a modified ethylene glycol (EG) reduction method and use as anode catalyst for a 15 cell, 1.5 kW proton exchange membrane fuel cell (PEMFC), with the main purpose of verifying the durability of the as-prepared catalyst. Polarization curves, line scan voltammograms (LSVs), and cyclic voltammograms (CVs) show that the 40% Ir-10% V/C anode is of comparable performance with a commercial Pt/C anode. After a 1010 h driving cycle test, the stack exhibits a minor degradation rate of 1.2% at rated power. The resulting performance and durability of the fuel cell stack demonstrate the as-prepared catalyst has the potential to be used in PEMFC. (C) 2011 Elsevier B.V. All rights reserved.