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Journal of Chemical Technology and Biotechnology, Vol.65, No.1, 3-4, 1996
Biocatalyst Replacement by Mimetics in Bioconversions - Can the Time-Scale Be Predicted
Enzyme mimics (mimetics) include abzymes (catalytic antibodies), RNA molecules (ribozymes), and enzyme analogues synthesized upon a polypeptide backbone structure (synzymes). Also, there is a variety of model systems such as the zeolite-membrane systems containing metal complexes, which mimic cytochrome P-450. Enzymes are being subjected to redesign procedures to introduce desired features such as thermostability that could improve their industrial usefulness : but even such novel enzymes may not be able in the near future to out-perform the enzyme mimics in all circumstances, such as at temperatures above about 120 degrees C or under completely non-aqueous conditions.
Keywords:ENZYME