In order to improve the efficiency of processes using supercritical (sc) carbon dioxide (CO2) to micronize the carotenoid "Iycopene", it is important to know the solubility of lycopene in mixtures of the organic solvent ethyl acetate (EA) and the antisolvent CO2 at elevated pressures. The solubility of lycopene has been determined for different temperatures (313-333 K), pressures (12-16 MPa) and CO2 molar fractions (0.58-1). The obtained data show that CO2 acts as an antisolvent in the system lycopene/EA/CO2 in the range of CO2/EA ratios studied. The solubility of lycopene is rather small with lycopene molar fractions ranging from 0.1 x 10(-6) to 46 x 10(-6). The solubility of lycopene increases with temperature, pressure and EA concentration. (C) 2012 Elsevier B.V. All rights reserved.