In this work, a continuous hydrothermal synthesis method in supercritical water was applied to environmentally benign production of Ca1-xSrxTiO3 (x = 0.0-1.0) solid-solution nanoparticles as key materials in conducting, electric, magnetic, and photocatalytic fields. AT-type micromixer (330 mu m id) was introduced for rapid heating of stating solutions of Ca(NO3)(2), Sr(NO3)(2), and TiO2 sol using turbulent flow mixing with preheated NaOH aqueous solution and also for exact control of reaction temperature. At 673 K and 30 MPa for 5.0 s mean residence time, Ca1-xSrxTiO3 solid-solution nanoparticles having crystallite diameters of around 20 nm with monomodal diameter distributions were obtained without byproducts and production of CaTiO3 and SrTiO3 separately over the whole composition range. Effects of NaOH molality, Ca and Sr compositions in the starting solutions, and mean residence time on the reaction were examined. The results showed that TiO2 sol dissolution and Ca1-xSrxTiO3 precipitation were almost finished within 0.25 s mean residence time, and after that Ostwald ripening proceeded. (C) 2013 Elsevier B.V. All rights reserved.