Journal of the American Chemical Society, Vol.136, No.20, 7217-7220, 2014
Enantioselective Insertion of a Carbenoid Carbon into a C-C Bond To Expand Cyclobutanols to Cyclopentanols
When a carbenoid species generated from a tosylhydrazone is reacted with a cyclobutanol in the presence of a chiral rhodium catalyst, a C-C single bond of the cyclobutanol is cleaved, and the carbenoid carbon is inserted therein to furnish a ring-expanded cyclopentanol in an enantioselective manner.