First generation biomaterials were developed to be as bioinert as possible to minimize rejection by host tissues. Second-generation biomaterials were designed to be either resorbable or bioactive, achieving positive interactions with the body. The next generation of biornaterials is combining these two properties, with the aim of developing materials that, once implanted, will help the body heal itself. The function of first and second generation biomaterials is to replace diseased or damaged parts of the body. Third generation biornaterials are designed to regenerate tissues.