Dense calcium phosphate (Ca-P) ceramics are used for the reconstruction of bone defects. A disadvantage of these materials is their difficulty to be properly delivered and moulded in order to achieve a desirable contour. To surpass these problems, calcium phosphate cements (Ca-P cements) have been developed. These materials are in contact with bone tissue as well as the surrounding soft tissues. Therefore, the biocompatibility of bone cements has to be evaluated in soft tissues as well as in a bony environment. This manuscript describes the in vivo soft tissue and bone reaction to an injectable CaP cement.