Bonelike(R) is synthetic bone graft designed to mimic the inorganic composition of new bone using a patent process that consists of liquid sintering hydroxyapatite in the presence of a CaO-P2O5 based glass. This work reports the clinical application of this novel bone graft in maxillofacial surgery to reconstruct a bone defected area after cyst excision. Histological results clearly demonstrated an extensive new bone formation after 6 months implantation, with a significant degree of maturation. Scanning electron microscopy analysis revealed that the Bonelike(R) granules were almost completely surrounded by new bone, which proves its high osteoconductive capacity.