This paper summarizes the results of detonation modeling of three types of explosive, namely Comp-B, PBXN-3 and PBXN-104; and two types of propellant, namely TPH-1205 and TPH-1206, using a reactive flow model in LS-DYNA. The reactive flow parameters developed for the Equation of State (EOS) # 7 in LS-DYNA can be used to predict shock initiation and detonation properties of these explosive and propellants in various hazard or intentional initiation scenarios. The more available are the experimental data for the calibration, the more reliable is the reactive flow model. Therefore, the model developed here for Comp-B is most reliable because Comp-B has been widely studied. TPH-1206 and similar HMX-based propellants have been studied to a lesser extent. Only one shock initiation experiment has been reported for PBXN-3 and none for PBXN-104, but since they are HMX-based explosive, reactive flow models have been developed based on other HMX explosive. TPH-1205 and similar non-HMX propellants are inert to shock initiation and are modeled as such.