The changes in the microhardness and Young's modulus of the 2 MeV C+ ion-irradiated IG-110 isotropic nuclear graphite were evaluated by a dynamic ultra-microhardness test. Indentation depth and load dependency of the hardness and elastic modulus were observed possibly due to the formation of a range. Both the hardness and Young's modulus (E) - dpa curves have shown an incubation dose for about 0.3 mdpa. After the incubation dose, both the hardness and E showed a rapid increase with the dose. The doses that corresponds to these rapid increases in the hardness and E coincides with the dose that corresponds to the beginning of the irradiation-induced surface distortion, and the loss of the graphite crystallinity (amorphization).