A composite of needle-like nano-hydroxyapatite (n-HA)/poly (D,L) lactide (PDLLA) was prepared. The n-HA crystals were poorly crystallized and uniformly distributed in the composite with a crystal size of 10-20 nm in diameter by 40-60nm in length, which was smaller than that of pure nano-HA. Molecular interactions and chemical bonds might present between n-HA and PDLLA in the composite, which were revealed by IR and XPS. The synthetic n-HA/PDLLA composite had a good homogeneity and could be a bioactive material for bone defect especially for load-bearing bone repair, which is more potential than pure HA or pure PDLLA.