The objective of this study was to optimize the casting design of gamma titanium aluminde automotive turbocharger rotor by means of the practical experiment and numerical simulation. Gamma titanium aluminide rotors were produced by centrifugal casting methods on a laboratory scale. Based on the metal-mold reaction of gamma titanium aluminide, the investment molds were manufactured by an electro-fused Al2O3 mold. The experimental results showed that the castings failed to reach the end of the cavities due to insufficient centrifugal force and a lower fluidity compared to the other metals. Although the satisfactory results were not obtained in the numerical simulation, it was concluded that numerical simulation aided to achieve understanding of the casting process and defect formation in gamma titanium aluminide turbocharger rotor castings.