The influences of temperature, strain rate, strain on mechanical parameters and microstructure evolution in isothermal deformation of GH4169 alloy were investigated. Lower resistance is obtained under higher temperature and lower strain rate. However, the microstructure is coarse after deformation under such condition. The tensile property at room temperature and elevated temperature, permanent properties at elevated temperature of the alloy with the treatment of "direct aging after isothermal deformation" are better than those with the treatment of solid-solution+aging after isothermal deformation. Isothermal forming of a 1/4 size simulated part of a kind of turbo disk of an aviation engine was undertaken; the external of the part is fine, and the microstructure of the material was fine and homogeneous after forming+direct aging.