Powder polymer processing was used to prepare immiscible PMMA/HDPE blends from micrometer sized polymer spheres that were physically mixed prior to compression molding to a fused blended film. This two-stage mixing approach, initially as dry powders and subsequently during compression molding, seeks to minimize the time/temperature/shear to which delicate thermoplastic polymers would otherwise be exposed by conventional extrusion processing. The powder processing route effectively generates fine domain blends (3-10 mu m) similar to extruded blends, although some coalescence was present. Conformational effects were observed by FTIR at high wavenumbers, indicating intimate interfacial proximity. The spectral effects are similar to those observed in extruded pellet blends. This powder processing route will be useful for molding delicate thermoplastic polymers found in certain biomaterial, pharmaceutical, and cosmetic applications. (C) 2011 Elsevier B.V. All rights reserved.