Heat transfer of a nanofluid flow which is squeezed between parallel plates is investigated analytically using homotopy perturbation method (HPM). Copper as nanoparticle with water as its base fluid has been considered. The effective thermal conductivity and viscosity of nanofluid are calculated by the Maxwell-Gametts (MG) and Brinkman models, respectively. This investigation is compared with other numerical methods and they were found to be in excellent agreement. The effects of the squeeze number, the nanofluid volume fraction and Eckert number and delta on Nusselt number are investigated. The results show that Nusselt number has direct relationship with nanoparticle volume fraction, delta, the squeeze number and Eckert number when two plates are separated but it has reverse relationship with the squeeze number when two plates are squeezed. (C) 2012 Elsevier B.V. All rights reserved.