One reason why butanol fermentation is not economically feasible has to do with the energy intensity of the product separation from the broth. In this study, a new approach for liquid-liquid extraction is presented. Several solvents, previously ignored because of their non-biocompatibility, were tested and a continuous process utilizing a novel, dual extraction with solvent regeneration is proposed. The optimal solvents for this process are from nine to eleven carbon alcohols used in conjunction with alkanes of approximately the same size. The ability to use non-biocompatible, but quite effective solvents offers a significant advantage, which is why a very low energy consumption of 3.76 MJ kg(-1) butanol is achieved with this new process. (C) 2014 Elsevier B.V. All rights reserved.