A theoretical model based on the force balance between pressure, viscous force, and inertia force is proposed to predict the flow resistance of Newtonian and power-law non-Newtonian fluids through porous packed beds. The present model takes inertia effect into consideration, and the flow regime can be extended from Darcy flow to non-Darcy flow. It is demonstrated that the present model can predict most available experimental data well. The present results are also compared to the Ergun equation and other drag correlations.