A new palladium catalyst based on a mesoporous polymer monolith has been introduced. A polyacrylonitrile (PAN) monolith prepared by a phase separation technique was used as precursor material for chemical modification; the nitrile groups on the monolith surface were transformed into amidine groups and then bound to palladium dichloride via coordination. A series of Suzuki-Miyaura cross-coupling reactions were successfully demonstrated by using the monolith as catalyst. Moreover, the monolith was found to exhibit excellent stability for repeated use. (C) 2014 Elsevier Ltd. All rights reserved.