In this communication a modeling method based on neural network technique and molecular properties has been proposed to model solubility of carbon dioxide, carbon monoxide, argon, oxygen, nitrogen, methane and ethane in 1-butyl-3-methylimidazolium tetrafluoroborate. Molecular weight and acentric factor (i.e. sphericity of molecule) are two network inputs which indicate the structure of gas molecule. Absolute temperature and pressure are two other inputs which exhibit macroscopic condition of studied system. Low deviations during training, validating and testing stages confirmed that the model is reliable within the studied range. Also, the proposed method is able to provide reliable gas solubility estimations based on available solubility data of other gases. This unique capability, which confirms superiority of applied method over traditional methods, enables researchers and engineers to provide acceptable gas solubility estimations without performing long time experiments. (C) 2012 Elsevier B.V. All rights reserved.