Natural Oil-based chemiluminescent nanodroplets for In vivo imaging of hydrogen peroxide

Ajay Singh; Hong-Jun Cho; Sangyoup Lee; Joonseok Koh; Sehoon Kim

Macromolecular Research, Vol.22, No.10, 1136-1139, October, 2014

DOI10.1007/s13233-014-2148-0 Export Citation

Natural Oil-based chemiluminescent nanodroplets for In vivo imaging of hydrogen peroxide

Ajay Singh^{1, 2}, Hong-Jun Cho², Sangyoup Lee², Joonseok Koh^{1, 3, †}, and Sehoon Kim^{2, †}

¹Department of Organic and Nano System Engineering, Konkuk University, Seoul, 143-701, Korea
²Center for Theragnosis, Korea Institute of Science and Technology, Seoul, 136-791, Korea
³, Korea

E-mail:,

A fuel-fluorophore concentrated oil nanodroplet enhances sensitivity toward hydrogen peroxide, and boosts near-infrared chemiluminescence generation with sustained emission. The cover image figuratively shows the event of chemiluminescence generation drop. The greatly boosted sensing signal visualizes endogenously overproduced hydrogen peroxide in vivo, allowing early diagnosis of diseases.

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[1] Chen R, Zhang L, Gao J, Wu W, Hu Y, Jiang X, J. Biomed. Biotechnol., 9, 1 (2011)

[2] Lee D, Khaja S, Velasquez-Castano JC, Dasari M, Sun C, Petros J, Taylor WR, Murthy N, Nat. Mater., 6(10), 765 (2007)

[3] Lee D, Erigala VR, Dasari M, Yu J, Dickson RM, Murthy N, Int. J. Nanomedicine, 3, 471 (2008)

[4] Bittner GCV, Dubikovskaya EA, Bertozzi CR, Chang CJ, Proc. Natl. Acad. Sci. U.S.A, 107, 21316 (2010)

[5] Arnous A, Petrakis C, Makris DP, Kefalas P, J. Pharmacol. Toxicol. Methods, 48, 171 (2002)

[6] Lin JM, Yamada M, Trends Anal. Chem., 22, 99 (2003)

[7] Kamyshny A, Magdassi S, Colloids Surf. B, 11, 249 (1998)

[8] Kim S, Ohulchanskyy TY, Baev A, Prasad PN, J. Mater. Chem., 19, 3181 (2009)

[9] Birks JB, Photophysics of Aromatic Molecules, Wiley, London (1970)

[10] Lee D, Khaja S, Velasquez-Castano JC, Dasari M, Sun C, Petros J, Taylor WR, Murthy N, Nat. Mater., 6(10), 765 (2007)

[11] Giorgio M, Trinei M, Migliaccio E, Pelicci PG, Nat. Rev. Mol. Cell Biol., 8, 722 (2007)

[12] Stimpson SA, Esser RE, Carter PB, Sartor RB, Cromartie WJ, Schwab JH, J. Exp. Med., 165, 1688 (1987)

[13] Wittmann C, Chockley P, Singh SK, Pase L, Lieschke GJ, Grabher C, Adv. Hematol., 2012, 541471 (2012)

[14] Cohen S, Magdassi S, Langmuir, 12(16), 3759 (1996)