Studies on encapsulation of Rifampicin and its release from chitosan-dextran sulfate capsules

M. Geetha Devi; Susmita Dutta; Ashraf Talib Al Hinai; S. Feroz

Korean Journal of Chemical Engineering, Vol.32, No.1, 118-124, January, 2015

DOI10.1007/s11814-014-0161-9 Export Citation

Studies on encapsulation of Rifampicin and its release from chitosan-dextran sulfate capsules

M. Geetha Devi^†, Susmita Dutta, Ashraf Talib Al Hinai¹, and S. Feroz²

Department of Chemical Engineering, National Institute of Technology Durgapur, India
¹Department of Chemistry, Sultan Quaboos University, Sultanate of Oman
²Caledonian College of Engineering, Sultanate of Oman

E-mail:

Biodegradable capsules of size around 350 nm were prepared by layer-by-layer (L-b-L) assembly of oppositely charged chitosan and dextran sulfate on silica particles and the subsequent removal of template. The resulting capsules were loaded with rifampicin, an anti-tuberculosis drug under modest conditions, as demonstrated by scanning electron microscopy (SEM). Maximum encapsulation of rifampicin was found to be about 82 μg at 25 ℃ and pH of 3. Release studies were done in-vitro mode by semiautomatic release protocol, with different pH solutions in water and phosphate buffered saline (PBS). The microcapsules exhibited a slow and sustained release over 72 hours and maximum release was obtained at a pH of 1.2 in water and a pH of 7.4 in PBS. The size of silica particle was analyzed by dynamic light scattering method. Scanning electron microscopy (SEM) measurements showed the surface morphology of the hollow capsules. UV spectroscopy was employed to monitor the drug release processes in both solutions. The kinetics of drug release mechanism was studied using Ritger-Peppas and Higuchi models.

Keywords:Biodegradable Capsules;Chitosan;Dextran Sulfate;Drug Release;Encapsulation;Microcapsules;Rifampicin

[References]

McCullosch, Iain, Shalaby SW, Eds., American Chemical Society, Washington, DC (1998)
Uhrich KE, Cannizzaro SM, Langer RS, Shakesheff KM, Chem. Rev., 99(11), 3181 (1999)
Yang L, Alexandridis P, Curr. Opin. Colloid Interface Sci., 5, 132 (2000)
Lee KY, Peters MC, Anderson KW, Mooney DJ, Nature, 408, 998 (2000)
Yang X, Han X, Zhu Y, Colloids Surf. A Physiochem. Eng. Asp., 264, 49 (2005)
Itoh Y, Matsusaki M, Kida T, Akashi M, Biomacromolecules, 7(10), 2715 (2006)
Kwak NS, Baek Y, Hwang TS, J. Hazard. Mater., 203, 213 (2012)
Decher G, Hong JD, Makromol. Chem. Macromol. Symp., 46, 321 (1991)
Decher G, Science, 277(5330), 1232 (1997)
Caruso F, Caruso RA, Mohwald H, Science, 282(5391), 1111 (1998)
Donath E, Sukhorukov GB, Caruso F, Davis SA, Mohwald H, Angew. Chem. Int. Ed., 37, 2202 (1998)
Fukui Y, Fujimoto K, Langmuir, 25, 1002 (2009)
Angelini G, Boncompagni S, De Maria P, Fontana A, Gasbarri C, Siani G, Colloids Surf. A., 322, 234 (2008)
Fan YF, Wang YN, Fan YG, Ma JB, Int. J. Pharm., 324, 158 (2006)
Haidar ZS, Hamdy RC, Tabrizian M, Biomaterials, 29, 1207 (2008)
Tan JPK, Wang Q, Tam KC, J. Controlled Release, 128, 248 (2008)
Peyratout CS, Dahne L, Angew. Chem., Int. Ed., 43, 3762 (2004)
Sabitha P, Vijaya Ratna J, Ravindra Reddy K, Int. J. Chem. Technol. Res., 2, 88 (2010)
Anil Kumar KN, Basuray S, Nahgaraja V, Raichur AM, Mater. Sci. Eng. C., 29(8), 2508 (2009)
Farnaz E, Mahdi H, Mazda R, Nasrin S, Fatemeh A, Rassoul D, Nanomedicine: Nanotechnology, Biology and Medicine, 3, 2 (2007)
Sasaki T, Matsuura H, Tanaka K, ISRN Polymer Science, 2014, Article ID 128154, http://dx.doi.org/10.1155/2014/128154. (2014)
Zivanovic S, Li JJ, Davidson PM, Kit K, Biomacromolecules, 8(5), 1505 (2007)
Felt O, Furrer P, Mayer JM, Plazonnet B, Buri P, Gurny R, Int. J. Pharm., 180, 185 (1999)
Patashnik S, Rabinovich L, Golomb G, J. Drug Target., 4, 371 (1997)
Song JS, Such CH, Park YB, Lee SH, Yoo NC, Lee JD, Kim KH, Lee SK, Eur. J. Nucl. Med., 28, 489 (2001)
Muzzarelli RAA, Cell Mol. Life Sci., 53, 131 (1997)
Koga D, Chen R, Chen HC, Adv. Chitin Sci., 3, 16 (1998)
Junginger HE, Verhoef JC, PSTT, 1, 370 (1998)
Kotze AF, Luessen HL, Thanou M, Verhoef JC, de Boer AG, Junginger HE, Lehr CM, Mathiowitz E, Chickering III DE, Lehr CM (Eds.), Bioadhesive Drug Delivery Systems, Marcel Dekker, New York, 341 (1999)
He P, Davis SS, Illum L, Int. J. Pharm., 166, 75 (1998)
Calvo P, Vila-Jato JL, Alonso MJ, Int. J. Pharm., 153, 41 (1997)
Biagini G, Muzzarelli RAA, Giardino R, Castaldini C, Brine CJ, Sandford PA, Zikakis JP (Eds.), Advances in Chitin and Chitosan, vol. 1, Elsevier Science, Barking, 16 (1992)
Ueno H, Mori T, Fujinaga T, Adv. Drug Deliv. Rev., 52, 105 (2001)
Felt O, Carrel A, Baehni P, Buri P, Gurny R, J. Ocul. Pharmacol. Ther., 16, 261 (2000)
Caruso F, Yang WJ, Trau D, Renneberg R, Langmuir, 16(23), 8932 (2000)
Antipov AA, Sukhorukov GB, Donath E, Mohwald H, J. Phys. Chem. B, 105(12), 2281 (2001)
Liu XF, Guan YL, Yang DZ, Li Z, De Yao K, J. Appl. Polym. Sci., 79(7), 1324 (2001)
Schatz C, Domard A, Viton C, Pichot C, Delair T, Biomacromolecules, 5(5), 1882 (2004)
Bogush MA, Tracy CF, Zukoski IV CF, J. Non-Crystalline Solids, 104, 95 (1988)
Stober W, Fink A, Boahn E, J. Coll. Int. Science, 26, 62 (1968)
Liang ZP, Liang CY, Sun QL, Tong Z, Prog. Chem., 16, 485 (2004)
Voigt A, Lichtenfeld H, Sukhorukov GB, Zastrow H, Donath E, Baumler H, Mohwald H, Ind. Eng. Chem. Res., 38(10), 4037 (1999)
Peppas NA, Pharm. Acta Helv., 60, 110 (1985)
Higuchi T, J. Pharm. Sci., 51, 1145 (1963)
Mao Z, Ma L, Gao C, J. Cont. Release., 104, 193 (2005)
Devi MG, Dutta S, Al Hinai AT, Feroz S, Indian Chem. Eng., 45, 1 (2013)

[Referenced By]

[1] McCullosch, Iain, Shalaby SW, Eds., American Chemical Society, Washington, DC (1998)

[2] Uhrich KE, Cannizzaro SM, Langer RS, Shakesheff KM, Chem. Rev., 99(11), 3181 (1999)

[3] Yang L, Alexandridis P, Curr. Opin. Colloid Interface Sci., 5, 132 (2000)

[4] Lee KY, Peters MC, Anderson KW, Mooney DJ, Nature, 408, 998 (2000)

[5] Yang X, Han X, Zhu Y, Colloids Surf. A Physiochem. Eng. Asp., 264, 49 (2005)

[6] Itoh Y, Matsusaki M, Kida T, Akashi M, Biomacromolecules, 7(10), 2715 (2006)

[7] Kwak NS, Baek Y, Hwang TS, J. Hazard. Mater., 203, 213 (2012)

[8] Decher G, Hong JD, Makromol. Chem. Macromol. Symp., 46, 321 (1991)

[9] Decher G, Science, 277(5330), 1232 (1997)

[10] Caruso F, Caruso RA, Mohwald H, Science, 282(5391), 1111 (1998)

[11] Donath E, Sukhorukov GB, Caruso F, Davis SA, Mohwald H, Angew. Chem. Int. Ed., 37, 2202 (1998)

[12] Fukui Y, Fujimoto K, Langmuir, 25, 1002 (2009)

[13] Angelini G, Boncompagni S, De Maria P, Fontana A, Gasbarri C, Siani G, Colloids Surf. A., 322, 234 (2008)

[14] Fan YF, Wang YN, Fan YG, Ma JB, Int. J. Pharm., 324, 158 (2006)

[15] Haidar ZS, Hamdy RC, Tabrizian M, Biomaterials, 29, 1207 (2008)

[16] Tan JPK, Wang Q, Tam KC, J. Controlled Release, 128, 248 (2008)

[17] Peyratout CS, Dahne L, Angew. Chem., Int. Ed., 43, 3762 (2004)

[18] Sabitha P, Vijaya Ratna J, Ravindra Reddy K, Int. J. Chem. Technol. Res., 2, 88 (2010)

[19] Anil Kumar KN, Basuray S, Nahgaraja V, Raichur AM, Mater. Sci. Eng. C., 29(8), 2508 (2009)

[20] Farnaz E, Mahdi H, Mazda R, Nasrin S, Fatemeh A, Rassoul D, Nanomedicine: Nanotechnology, Biology and Medicine, 3, 2 (2007)

[21] Sasaki T, Matsuura H, Tanaka K, ISRN Polymer Science, 2014, Article ID 128154, http://dx.doi.org/10.1155/2014/128154. (2014)

[22] Zivanovic S, Li JJ, Davidson PM, Kit K, Biomacromolecules, 8(5), 1505 (2007)

[23] Felt O, Furrer P, Mayer JM, Plazonnet B, Buri P, Gurny R, Int. J. Pharm., 180, 185 (1999)

[24] Patashnik S, Rabinovich L, Golomb G, J. Drug Target., 4, 371 (1997)

[25] Song JS, Such CH, Park YB, Lee SH, Yoo NC, Lee JD, Kim KH, Lee SK, Eur. J. Nucl. Med., 28, 489 (2001)

[26] Muzzarelli RAA, Cell Mol. Life Sci., 53, 131 (1997)

[27] Koga D, Chen R, Chen HC, Adv. Chitin Sci., 3, 16 (1998)

[28] Junginger HE, Verhoef JC, PSTT, 1, 370 (1998)

[29] Kotze AF, Luessen HL, Thanou M, Verhoef JC, de Boer AG, Junginger HE, Lehr CM, Mathiowitz E, Chickering III DE, Lehr CM (Eds.), Bioadhesive Drug Delivery Systems, Marcel Dekker, New York, 341 (1999)

[30] He P, Davis SS, Illum L, Int. J. Pharm., 166, 75 (1998)

[31] Calvo P, Vila-Jato JL, Alonso MJ, Int. J. Pharm., 153, 41 (1997)

[32] Biagini G, Muzzarelli RAA, Giardino R, Castaldini C, Brine CJ, Sandford PA, Zikakis JP (Eds.), Advances in Chitin and Chitosan, vol. 1, Elsevier Science, Barking, 16 (1992)

[33] Ueno H, Mori T, Fujinaga T, Adv. Drug Deliv. Rev., 52, 105 (2001)

[34] Felt O, Carrel A, Baehni P, Buri P, Gurny R, J. Ocul. Pharmacol. Ther., 16, 261 (2000)

[35] Caruso F, Yang WJ, Trau D, Renneberg R, Langmuir, 16(23), 8932 (2000)

[36] Antipov AA, Sukhorukov GB, Donath E, Mohwald H, J. Phys. Chem. B, 105(12), 2281 (2001)

[37] Liu XF, Guan YL, Yang DZ, Li Z, De Yao K, J. Appl. Polym. Sci., 79(7), 1324 (2001)

[38] Schatz C, Domard A, Viton C, Pichot C, Delair T, Biomacromolecules, 5(5), 1882 (2004)

[39] Bogush MA, Tracy CF, Zukoski IV CF, J. Non-Crystalline Solids, 104, 95 (1988)

[40] Stober W, Fink A, Boahn E, J. Coll. Int. Science, 26, 62 (1968)

[41] Liang ZP, Liang CY, Sun QL, Tong Z, Prog. Chem., 16, 485 (2004)

[42] Voigt A, Lichtenfeld H, Sukhorukov GB, Zastrow H, Donath E, Baumler H, Mohwald H, Ind. Eng. Chem. Res., 38(10), 4037 (1999)

[43] Peppas NA, Pharm. Acta Helv., 60, 110 (1985)

[44] Higuchi T, J. Pharm. Sci., 51, 1145 (1963)

[45] Mao Z, Ma L, Gao C, J. Cont. Release., 104, 193 (2005)

[46] Devi MG, Dutta S, Al Hinai AT, Feroz S, Indian Chem. Eng., 45, 1 (2013)