NaOH 처리에 따른 다공성 PCL 지지체의 의사체액 환경에서의 아파타이트 형성

이향미; 진형호; 현용택; 박홍채; 윤석영; Hyang-Mi Lee; Hyeong-Ho Jin; Yong-Taek Hyun; Hong-Chae Park; Seog-Young Yoon

Korean Journal of Materials Research, Vol.17, No.11, 622-627, November, 2007

DOI10.3740/MRSK.2007.17.11.622 Export Citation

NaOH 처리에 따른 다공성 PCL 지지체의 의사체액 환경에서의 아파타이트 형성

Apatite Formation of NaOH-treated Porous PCL Scaffolds in Simulated Body Fluid

이향미, 진형호, 현용택¹, 박홍채 , 윤석영 ^†

부산대학교 재료공학부
¹한국기계연구원 재료기술연구소 미래기술연구부

Hyang-Mi Lee, Hyeong-Ho Jin, Yong-Taek Hyun¹, Hong-Chae Park , and Seog-Young Yoon^†

School of Materials Science and Engineering, Pusan National University, Busan 609-735, Korea
¹Department of Future Technology, Korea Institute of Machinery and Materials, Changwon 641-010, Korea

E-mail:

Porous poly(e-caprolactone) (PCL) scaffolds were fabricated by salt leaching method. The PCL scaffolds were treated with aqueous NaOH for 0h, 2h, 4h, 8h, and 12h at 40oC. The NaOH-treated PCL scaffolds were dipped in CaCl2 and K2HPO4 · 3H2O solution alternately three times to induce apatite nuclei onto the surface of the scaffolds. The NaOH-treated PCL scaffolds were immersed into SBF solution for 1day to grow the apatite. The apatite formation were investigated as a fuction of NaOH treatment time. The hydrophilicty and surface area of the PCL scaffolds were increased with NaOH treatment time. The NaOHtreated PCL scaffolds were successfully formed a dense and uniform bone-like apatite layer after immersion for 1 day in SBF solution.

Keywords:PCL;Scaffolds;NaOH;SBF;Biomimetic

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