방전플라즈마소결법에 의해 제조된 저탄성 타이타늄 다공질체의 생체적합성 평가

송호연; 김영희; 장세훈; 오익현; Ho-Yeon Song; Young-Hee Kim; Se-Hun Chang; Ik-Hyun Oh

Korean Journal of Materials Research, Vol.17, No.2, 107-114, February, 2007

DOI10.3740/MRSK.2007.17.2.107 Export Citation

방전플라즈마소결법에 의해 제조된 저탄성 타이타늄 다공질체의 생체적합성 평가

Biocompatibility of Low Modulus Porous Titanium Implants Fabricated by Spark Plasma Sintering

송호연^†, 김영희, 장세훈¹, 오익현¹

순천향대학교 의과대학
¹한국생산기술연구원 광주연구센터

Ho-Yeon Song^†, Young-Hee Kim, Se-Hun Chang¹, and Ik-Hyun Oh¹

Department of Microbiology, School of Medicine, Soonchunhyang University, 330-090, South Korea
¹Gwangju Research Center, Korea Institute of Indutrial Technology(KITECH), Gwangju, 506-824, Korea

E-mail:

Porous Ti compacts were fabricated by spark plasma sintering (SPS) method and their in vitro and in vivo biocompatibilities were investigated. Alkaline phosphatase (ALP) activity representing the activity of osteoblast was increased when osteoblast-like MG-63 cells were cultured on the Ti powder surface. Some genes related to cell growth were over-expressed through microarray analysis. The porous Ti compact with 32.2% of porosity was implanted in the subcutaneous tissue of rats to confirm in vivo cytotoxicity. 12 weeks post-operation, outer surface and inside the porous body was fully filled with fibrous tissue and the formation of new blood vessels were observed. No inflammatory response was confirmed. To investigate the osteoinduction, porous Ti compact was implanted in the femur of NZW rabbits for 4 months. Active in-growth of new bone from the surrounded compact bone was observed around the porous body. From the results, The porous Ti compacts fabricated by spark plasma sintering might be available for the application of the stem part of artificial hip joint.

Keywords:Spark plasma sintering;Porous titanium;Biocompatibility

[References]

Hwang DS, Shanbhang AS, Bailey HO, Rubash HE, J. Kor. Hip. Soc., 7, 149 (1995)
Kieswetter K, Schwartz Z, Hummert TW, Cochran DL, Simpson J, Dean DD, Boyan BD, J. Biomed. Mater. Res., 32, 55 (1996)
Wagner M, Wagner H, Clin. Orthop., 379, 123 (2000)
Garino JP, Clin. Orthop., 379, 41 (2000)
Sedel L, Clin. Orthop., 379, 48 (2000)
Sedel L, Bizot P, Nizard R, Meunier A, Semin. Arthroplasty, 9, 123 (1998)
Winter M, Griss P, Scheller G, Clin. Orthop., 282, 73 (1992)
Li BY, Long LJ, Li YY, Gjunter VE, Acta Mater., 48, 38 (2000)
Kuroda D, Minomi M, Morinaga M, Kato Y, Yashiro T, Mater. Sci. Eng., 243, 2 (1989)
Okazaki Y, Nishimura E, Nakada H, Kobayashi K, Biomaterials, 22, 5 (2001)
Long M, Rack HJ, Biomaterials, 19, 16 (1998)
Whiteside E, Clin. Orthop., 248, 2 (1998)
Oh IH, Son HT, Chang SH, Kim HM, Lee KY, Park SS, Song HY, J. Kor. Inst. Met & Mater, 44, 6 (2006)
Thieme M, Witeter KP, Bergner F, Scharnweber D, Worch H, Ndop J, Mater. Sci. Forum., 308, 3 (1999)

[1] Hwang DS, Shanbhang AS, Bailey HO, Rubash HE, J. Kor. Hip. Soc., 7, 149 (1995)

[2] Kieswetter K, Schwartz Z, Hummert TW, Cochran DL, Simpson J, Dean DD, Boyan BD, J. Biomed. Mater. Res., 32, 55 (1996)

[3] Wagner M, Wagner H, Clin. Orthop., 379, 123 (2000)

[4] Garino JP, Clin. Orthop., 379, 41 (2000)

[5] Sedel L, Clin. Orthop., 379, 48 (2000)

[6] Sedel L, Bizot P, Nizard R, Meunier A, Semin. Arthroplasty, 9, 123 (1998)

[7] Winter M, Griss P, Scheller G, Clin. Orthop., 282, 73 (1992)

[8] Li BY, Long LJ, Li YY, Gjunter VE, Acta Mater., 48, 38 (2000)

[9] Kuroda D, Minomi M, Morinaga M, Kato Y, Yashiro T, Mater. Sci. Eng., 243, 2 (1989)

[10] Okazaki Y, Nishimura E, Nakada H, Kobayashi K, Biomaterials, 22, 5 (2001)

[11] Long M, Rack HJ, Biomaterials, 19, 16 (1998)

[12] Whiteside E, Clin. Orthop., 248, 2 (1998)

[13] Oh IH, Son HT, Chang SH, Kim HM, Lee KY, Park SS, Song HY, J. Kor. Inst. Met & Mater, 44, 6 (2006)

[14] Thieme M, Witeter KP, Bergner F, Scharnweber D, Worch H, Ndop J, Mater. Sci. Forum., 308, 3 (1999)