Suturing property of tough double network hydrogels for bio-repair materials

Yang Ho Na; Hwa Yeon Oh; Young Ju Ahn; Youngbae Han

Korea-Australia Rheology Journal, Vol.27, No.1, 25-31, February, 2015

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Suturing property of tough double network hydrogels for bio-repair materials

Yang Ho Na, Hwa Yeon Oh, Young Ju Ahn¹, and Youngbae Han^{1, †}

Department of Advanced Materials, Hannam University, Jeonmin-dong 461-6, Yuseong-gu, Daejeon 305-811, Republic of Korea
¹Department of Mechanical and Design Engineering, Hongik University, Sejong-ro 2639, Jochiwon-eup, Sejong 339-701, Republic of Korea

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Cartilage and meniscal lesions have limited potential for spontaneous repair. Consequently, much effort has been made to develop methods for repairing such lesions. Double-network (DN) gels are new candidatematerials for repairing such lesions. They exhibit exceptional mechanical strength and toughness in spite of their high water content. In this study, we prepared highly tough DN hydrogels and investigated the mechanical properties related to clinical implant use. The mechanical properties such as Young’s modulus and suture tear-out strength were measured for the artificial replacement. The results suggest that the suture property of DN hydrogels can be adjusted by controlling the crosslinking density and monomer concentration. Finite element method was also applied to these DN hydrogels in order to check whether the fracture strength of the material is enough to meet a medical purpose.

Keywords:hydrogels;cartilage repair;suturing;finite element method

[References]

Arnold MP, Daniels AU, Ronken S, Garcia HA, Friederich NF, Kurokawa T, Gong JP, Wirz D, Cartilage, 2, 374 (2011)
Chen GH, Hoffman AS, Nature, 373(6509), 49 (1995)
Chen Q, Colby RH, Korea-Aust. Rheol. J., 26(3), 257 (2014)
Diehl T, Int. J. Adhes. Adhes., 28, 237 (2008)
Drury JL, Mooney DJ, Biomaterials, 24, 4337 (2003)
Garcia HA, Daniels AU, Wirz D, Eur. Cells Mater., 16, 7 (2008)
Gong JP, Soft Matter, 6, 2583 (2010)
Gong JP, Kurokawa T, Narita T, Kagata G, Osada Y, Nishimura G, Kinjo M, J. Am. Chem. Soc., 123(23), 5582 (2001)
Gong JP, Katsuyama Y, Kurokawa T, Osada Y, Adv. Mater., 15(14), 1155 (2003)
Farhadi J, Fulco I, Miot S, Wirz D, Haug M, Dickinson SC, Ann. Surg., 244, 978 (2006)
Farhadi J, Fulco I, Miot S, Wirz D, Haug M, Dickinson SC, Ann. Surg., 244, 978 (2006)
Langer R, Tirrell DA, Nature, 428, 487 (2004)
Na YH, Korea-Aust. Rheol. J., 25(4), 185 (2013)
Na YH, Kurokawa T, Katsuyama Y, Tsukeshiba H, Gong JP, Osada Y, Okabe S, Karino T, Shibayama M, Macromolecules, 37(14), 5370 (2004)
Na YH, Tanaka Y, Kawauchi Y, Furukawa H, Sumiyoshi T, Gong JP, Osada Y, Macromolecules, 39(14), 4641 (2006)
Nair AU, Hubert L, Bestelmeyer AM, Characterization of damage in hyperelastic materials using standard test methods and abaqus, 2009 SIMULIA Customer Conference, 1-15. (2009)
Osada Y, Okuzaki H, Hori H, Nature, 355, 242 (1992)
Tanaka Y, Nishio I, Sun ST, Ueno-Nishio S, Science, 218, 467 (1982)
Tsukeshiba H, Huang M, Na YH, Kurokawa T, Kuwabara R, Tanaka Y, Furukawa H, Osada Y, Gong JP, J. Phys. Chem. B, 109(34), 16304 (2005)
Wirz D, Kohelr K, Keller B, Gopfert D, Hudetz D, Daniels AU, J. Biomech., 41, 172 (2008)
Yoshida R, Takahashi T, Yamaguchi T, Ichijo H, Adv. Mater., 9(2), 175 (1997)

[Referenced By]

[1] Arnold MP, Daniels AU, Ronken S, Garcia HA, Friederich NF, Kurokawa T, Gong JP, Wirz D, Cartilage, 2, 374 (2011)

[2] Chen GH, Hoffman AS, Nature, 373(6509), 49 (1995)

[3] Chen Q, Colby RH, Korea-Aust. Rheol. J., 26(3), 257 (2014)

[4] Diehl T, Int. J. Adhes. Adhes., 28, 237 (2008)

[5] Drury JL, Mooney DJ, Biomaterials, 24, 4337 (2003)

[6] Garcia HA, Daniels AU, Wirz D, Eur. Cells Mater., 16, 7 (2008)

[7] Gong JP, Soft Matter, 6, 2583 (2010)

[8] Gong JP, Kurokawa T, Narita T, Kagata G, Osada Y, Nishimura G, Kinjo M, J. Am. Chem. Soc., 123(23), 5582 (2001)

[9] Gong JP, Katsuyama Y, Kurokawa T, Osada Y, Adv. Mater., 15(14), 1155 (2003)

[10] Farhadi J, Fulco I, Miot S, Wirz D, Haug M, Dickinson SC, Ann. Surg., 244, 978 (2006)

[11] Farhadi J, Fulco I, Miot S, Wirz D, Haug M, Dickinson SC, Ann. Surg., 244, 978 (2006)

[12] Langer R, Tirrell DA, Nature, 428, 487 (2004)

[13] Na YH, Korea-Aust. Rheol. J., 25(4), 185 (2013)

[14] Na YH, Kurokawa T, Katsuyama Y, Tsukeshiba H, Gong JP, Osada Y, Okabe S, Karino T, Shibayama M, Macromolecules, 37(14), 5370 (2004)

[15] Na YH, Tanaka Y, Kawauchi Y, Furukawa H, Sumiyoshi T, Gong JP, Osada Y, Macromolecules, 39(14), 4641 (2006)

[16] Nair AU, Hubert L, Bestelmeyer AM, Characterization of damage in hyperelastic materials using standard test methods and abaqus, 2009 SIMULIA Customer Conference, 1-15. (2009)

[17] Osada Y, Okuzaki H, Hori H, Nature, 355, 242 (1992)

[18] Tanaka Y, Nishio I, Sun ST, Ueno-Nishio S, Science, 218, 467 (1982)

[19] Tsukeshiba H, Huang M, Na YH, Kurokawa T, Kuwabara R, Tanaka Y, Furukawa H, Osada Y, Gong JP, J. Phys. Chem. B, 109(34), 16304 (2005)

[20] Wirz D, Kohelr K, Keller B, Gopfert D, Hudetz D, Daniels AU, J. Biomech., 41, 172 (2008)

[21] Yoshida R, Takahashi T, Yamaguchi T, Ichijo H, Adv. Mater., 9(2), 175 (1997)