화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Korean Journal of Chemical Engineering, Vol.32, No.3, 369-372, March, 2015
DOI10.1007/s11814-015-0007-0  Export Citation
Novel double-walled microspheres based on chitosan, sodium cellulose sulfate and sodium tripolyphosphate: Preparation, characterization and in vitro release study
Li-Ying Zhu1, 2, Xiao-Qin Yan1, Hong-Man Zhang1, Shan-Jing Yao2, and Ling Jiang3, †
  • 1College of Sciences, Nanjing University of Technology, Nanjing 211816, P. R. China
  • 2Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, P. R. China
  • 3College of Food Science and Light Industry, Nanjing University of Technology, Nanjing 211816, P. R. China
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A novel double-walled microsphere composed of chitosan, sodium cellulose sulfate (NaCS) and sodium tripolyphosphate (TPP) was prepared. TPP was used as ionic crosslinker. The morphology of the microspheres was observed by microscope and SEM, and the results showed that the double-walled microsphere was smooth outside, with rough interior surface. FTIR spectra analysis was performed to investigate the PEC formation among chitosan, NaCS, and TPP. In vitro release studies of BSA showed that the double-walled microspheres had regular and sustainable release profiles in simulated colonic fluid (SCF). Our results indicated that the double-walled microspheres prepared could be used as a candidate protein drug carrier for the colon.
Keywords:Chitosan;Sodium Cellulose Sulfate;Sodium Tripolyphosphate;Double-walled Microshperes;In Vitro Drug Release
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