표면 개질에 따른 Ti-8wt.%Ta-3wt.%Nb 합금의 생체적합성

이도재; 이경구; 박범수; 이광민; 박상원; Doh-Jae Lee; Kyung-Ku Lee; Bum-Su Park; Kwang-Min Lee; Sang-Won Park

Korean Journal of Materials Research, Vol.16, No.5, 277-284, May, 2006

DOI10.3740/MRSK.2006.16.5.277 Export Citation

표면 개질에 따른 Ti-8wt.%Ta-3wt.%Nb 합금의 생체적합성

Biocompatibility of Ti-8wt.%Ta-3wt.%Nb alloy with Surface Modification

이도재, 이경구^†, 박범수, 이광민, 박상원¹

전남대학교 공과대학 금속공학과
¹전남대학교 치과대학 보철학교실

Doh-Jae Lee, Kyung-Ku Lee^†, Bum-Su Park, Kwang-Min Lee, and Sang-Won Park¹

Dept. of Metallurgical Engineering, Chonnam National University, Korea
¹Dept. of Pristhodontics, School of Dentistry, Chonnam University University, Korea

E-mail:

The alloys were prepared by a non-consumable vacuum arc melting and homogenized at for 24 hrs. Two kind of surface modifications were performed alkali treatment in 5.0M NaOH solution subsequent and heat treatment in vacuum furnace at , and were oxidizing treatment at the temperature range of 550 to for 30 minutes. After surface modification, these samples were soaked in SBF which consists of nearly the same ion concentration as human blood plasma. Cytotoxicity tests were performed in MTT assay treated L929 fibroblast cell culture, using indirect methods. A porous and thin activated layer was formed on Titanium and Ti-8Ta-3Nb alloy by the alkali treatment. A bone-like hydroxyapatite was nucleated on the activated porous surfaces during the in vitro test. However, Ti-8Ta-3Nb alloys showed better bioactive properties than Titanium. According to XRD results, oxide layers composed of mostly (rutile) phases. Cytotoxicity test also revealed that moderate oxidation treatment lowers cell toxicity and Ti-8Ta-3Nb alloy showed better results compared with Titanium.

Keywords:biocompatibility;arc melting;titanium;alkali treatment

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[2] Agrawal CM, JOM, 31 (1998)

[3] Long M, Rack HJ, Biomaterials, 19, 6121 (1998)

[4] Petrunko AN, Anokhin VM, Titanium 95 science and technology, 2, 1816 (1995)

[5] Bordj K, Jouzeau JY, Biomaterials, 17(9), 929 (1996)

[6] Ahmed T, Long M, Silvestri J, Ruiz C, Rack HJ, Titanium 95 science and technology, 2, 1760 (1995)

[7] Landsberg JP, McDonald B, Watt F, Nature, 360, 65 (1992)

[8] Yumoto S, Nagai H, Kakimi S, Ogawa Y, Ishii K, Internation Journal of PIXE, 2(4), 493 (1992)

[9] Farrar G, Blair JA, Altmann P, Welch S, Wychrij O, Ghose B, Lejeune J, Corbett J, Prasher V, Lancet, 335, 747 (1990)

[10] Winship KA, Adverse Drug React. Toxicol. Rev., 11(2), 123 (1992)

[11] Velten D, Biehl V, Breme J, J. of Biomedical Materials Research, 59(1), 206 (2001)

[12] Shin GH, Lee KH, Lee CH, J. Kor. Inst. Met. & Mater., 39(2), 206 (2001)

[13] Li P, Groot K, J. Biomed. Mater. Res., 27, 1495 (1993)

[14] Ohtsuki C, Iida H, Hayakawa S, Osaka A, J. Biomed. Mater. Res, 35, 39 (1997)

[15] Kim HM, Miyaji F, Kokubo T, Nakamura T, J. Biomed. Mater. Res., 32, 409 (1996)

[16] Wen HB, Wolke JGC, Wijn JR, Liu Q, Cui FZ, De Groot K, Biomaterials, 18, 1471 (1997)

[17] Wen HB, Liu Q, Wijn JR, De Groot K, J. Mater. Sci. Mater. Med., 9, 121 (1998)

[18] Daeubler MA, Helm D, Lutjering G, Titanium '95 Science and Technology, 709 (1995)

[19] Boyer R, Welsch G, Collings EW : Materials properties of Handbook, Titanium alloys, ASMI (1994) (1994)

[20] Kim HM, Miyaji F, Kokubo T, Nakamura T, J. Mater. Sci. Mater. Med., 8, 341 (1997)

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[22] Kasemo B, Lausmaa, J. Biomaterial and implant surfaces, Int J Oral Maxillofacial Implants, 247 (1988)

[23] McAlarney ME, Oshiro MA, McAlarney CV, Int J Oral Maxillofac Implants, 73 (1996)