Electrospray ionization tandem mass spectrometry for rapid, sensitive and direct detection of melamine in dairy products

Suresh Kumar Kailasa; Hui-Fen Wu

Journal of Industrial and Engineering Chemistry, Vol.21, 138-144, January, 2015

DOI10.1016/j.jiec.2014.03.012 Export Citation

Electrospray ionization tandem mass spectrometry for rapid, sensitive and direct detection of melamine in dairy products

Suresh Kumar Kailasa^{1, 2}, and Hui-Fen Wu^{1, 3, †}

¹Department of Chemistry, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan
²Center for Nanoscience and Nanotechnology, Department of Chemistry, National Sun Yat-Sen University, S. V. National Institute of Technology, Kaohsiung 80424, Taiwan, Surat 395007, India
³Center for Nanoscience and Nanotechnology, Institute of Medical Science and Technology, School of Pharmacy, College of Pharmacy, Doctoral Degree Program in Marine Biotechnology, National Sun Yat-Sen University, Kaohsiung Medical University, Kaohsiung 80424, Taiwan, Kaohsiung 806, Taiwan

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A simple, rapid, and sensitive method for detection of melamine in dairy products by electrospray ionization mass spectrometry (ESI.MS) without any sample preparation is demonstrated. The ESI-MS/MS on the protonated melamine atm/z 127 produced the characteristic fragment ions atm/z 110, 85, 68, 60. This method has a good linearity in the range of 0.5-10.0 mg/mL, with detection limit 0.1 mg/mL and RSD 8.9% (n = 5). Together with existing recent methods on mass spectrometry and NP-based sensing methodologies for melamine detection, the present method provides an efficient platform for detection of melamine in milk products without any sample preparation steps or post-separation procedures.

Keywords:Melamine;Milk;Fruit juice;ESI-MS

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[1] Sugita T, Ishiwata H, Yoshihira K, Food Addit. Contam., 7, 21 (1990)

[2] Kim B, Perkins LB, Bushway RJ, Nesbit S, Fang T, Sheridan R, Greene V, J. AOAC Int., 91, 408 (2008)

[3] World Health Organization, Melamine Contamination Event, China, retrieved December 2, 2008, http://www.who.int/foodsafety/fs.management/infosan.events/en/index.html.

[4] Brown CA, Jeong KS, Poppenga RH, Puschner B, Miller DM, Ellis AE, Kang KI, Sum S, Cistola AM, Brown SA, J. Vet. Diagn. Invest., 19, 525 (2007)

[5] Dobson RL, Motlagh S, Quijano M, Cambron RT, Baker TR, Pullen AM, Regg BT, Bigalow-Kern AS, Vennard T, Fix A, Reimschuessel R, Overmann G, Shan Y, Daston GP, Toxicol. Sci., 106, 251 (2008)

[6] http://en.wikipedia.org/wiki/2008_baby_milk_scandal

[7] Sun F, Ma W, Xu L, Zhu Y, Liu L, Peng C, Wang L, Kuang H, Xu C, Trends Anal. Chem., 29, 1239 (2010)

[8] Lin M, He L, Awika J, Yang L, Ledoux DR, Li H, Mustapha A, J. Food Sci., 73, 129 (2008)

[9] Garber EAE, J. Food Prot., 71, 590 (2008)

[10] Cao Q, Zhao H, He Y, Li X, Zeng L, Ding N, Wang J, Yang J, Wang G, Biosens. Bioelectron., 25, 2680 (2010)

[11] Han C, Li H, Analyst, 135, 583 (2010)

[12] Chi H, Liu B, Guan G, Zhang Z, Han MY, Analyst, 135, 1070 (2010)

[13] Ding N, Yan N, Ren C, Chen X, Anal. Chem., 82, 5897 (2010)

[14] Cook HA, Klampfl CW, Buchberger W, Electrophoresis, 26(7-8), 1576 (2005)

[15] Klampfl CW, Andersen L, Haunschmidt M, Himmelsbach M, Buchberger W, Electrophoresis, 30(10), 1743 (2009)

[16] Ibanez M, Sancho JV, Hernandez F, Anal. Chim. Acta, 649, 91 (2009)

[17] Vaclavik L, Rosmus J, Popping B, Hajslova J, J. Chromatogr. A, 1217, 4204 (2010)

[18] Zhang M, Li S, Yu C, Liu G, Jia J, Lu C, He J, Ma Y, Zhu J, Yu C, J. Chromatogr. B, 878, 758 (2010)

[19] Cody RB, Laramee JA, Durst HD, Anal. Chem., 77, 2297 (2005)

[20] Harper JD, Charipar NA, Mulligan CC, Zhang X, Cooks RG, Ouyang Z, Anal. Chem., 80, 9097 (2010)

[21] Huang G, Xu W, Visbal-Onufrak MA, Ouyang Z, Cooks RG, Analyst, 135, 705 (2010)

[22] Takats Z, Wiseman JM, Gologan B, Cooks RG, Science, 306, 471 (2004)

[23] Yang SP, Ding JH, Zheng J, Hu B, Li JQ, Chen HW, Zhou ZQ, Qiao XL, Anal. Chem., 81, 2426 (2009)

[24] Zhu L, Gamez G, Chen HW, Chingin K, Zenobi R, Chem. Commun., 45, 559 (2009)

[25] Campbell JA, Wunschel DS, Peterson CE, Anal. Lett., 40, 3107 (2007)

[26] Arnold A, Arrey TN, Karas M, Persike M, Rapid Commun. Mass Spectrom., 25, 2844 (2011)

[27] Hsieh YT, Chen WT, Tomalova I, Preisler J, Chang HT, Rapid Commun. Mass Spectrom., 26, 1393 (2012)