Effect of tar compounds on the purification efficiency of paclitaxel from Taxus chinensis

Gyu-Yeon Park; Gun-Joong Kim; Jin-Hyun Kim

Journal of Industrial and Engineering Chemistry, Vol.21, 151-154, January, 2015

DOI10.1016/j.jiec.2014.03.042 Export Citation

Effect of tar compounds on the purification efficiency of paclitaxel from Taxus chinensis

Gyu-Yeon Park, Gun-Joong Kim, and Jin-Hyun Kim^†

Department of Chemical Engineering, Kongju National University, Cheonan 330-717, South Korea

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We investigated the effect of tar compounds on the purification efficiency of paclitaxel from Taxus chinensis and evaluated the adsorbent for their removal. The tar compounds had an adverse effect on the purifying process in increasing order of 1-methylnaphthalene, o-xylene < acenaphthene < 2-picoline < 2,5-xylenol. As a result of adsorbent treatment, HP20 gave the highest yield (97.8%) and purity (44.7%) of paclitaxel. The highest removal (85.2%) of major tar compounds in biomass was also obtained through adsorbent treatment with HP20. The purification efficiency of paclitaxel by adsorbent treatment increased as the removal of tar compounds increased.

Keywords:Paclitaxel;Tar compound;Removal;Adsorbent;Purification

[References]

Kim JH, Korean J. Biotechnol. Bioeng., 21, 1 (2006)
Hsiao JR, Leu SF, Huang BM, J. Oral Pathol. Med., 38, 188 (2009)
Rao KV, Hanuman JB, Alvarez C, Stoy M, Juchum J, Davies RM, Baxley R, Pharm. Res., 12, 1003 (1995)
Baloglu E, Kingston DG, J. Nat. Prod., 62, 1068 (1999)
Georgiev MI, Weber J, Maciuk A, Appl. Microbiol. Biotechnol., 83(5), 809 (2009)
Ghassempour A, Rezadoost H, Mashouf A, Aboul-Enein HY, Spengler B, Rompp A, Chromatographia, 72, 833 (2010)
Pyo SH, Song BK, Ju CH, Han BH, Choi HJ, Process Biochem., 40, 1113 (2005)
Kim JH, Kang IS, Choi HK, Hong SS, Lee HS, Process Biochem., 37, 679 (2002)
Rao KV, US Patent No. 5,670,673 (1997)
Castor TP, US Patent No. 5,750,709 (1998)
ElSohly HN, Croom EM, ElSohly MA, McChesney JD, US Patent No. 5,618,538 (1997)
Jeon KY, Kim JH, Process Biochem., 44, 736 (2009)
Lee JY, Kim JH, Sep. Purif. Technol., 80(2), 240 (2011)
Pyo SH, Park HB, Song BK, Han BH, Kim JH, Process Biochem., 39, 1985 (2004)
Oh HJ, Jang HR, Jung KY, Kim JH, Process Biochem., 47, 331 (2012)
Han MG, Jeon KY, Mun S, Kim JH, Process Biochem., 45, 1368 (2010)
Sim HA, Lee JY, Kim JH, Sep. Purif. Technol., 89, 112 (2012)
Kim GJ, Park GY, Kim JH, Korean J. Microbiol. Biotechnol., 41, 272 (2013)
Gamborg OL, Miller RA, Ojima K, Exp. Cell Res., 50, 151 (1968)
Choi HK, Adams TL, Stahlhut RW, Kim SI, Yun JH, Song BK, Kim JH, Hong SS, Lee HS, US Patent No. 5,871,979
Gregg SJ, Sing KSW, Adsorption, Surface Area and Porosity, 2nd ed., Academic Press, New York (1982)
Lee JY, Kim JH, Sep. Purif. Technol., 103, 8 (2013)
Kim JH, Hong SS, Korean J. Biotechnol. Bioeng., 15, 366 (2000)
Hu X, Hanaoka T, Sakanishi K, Shinagawa T, Matsui S, Tada M, Iwasaki T, J. Japan Inst. Energy, 86, 707 (2007)

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[1] Kim JH, Korean J. Biotechnol. Bioeng., 21, 1 (2006)

[2] Hsiao JR, Leu SF, Huang BM, J. Oral Pathol. Med., 38, 188 (2009)

[3] Rao KV, Hanuman JB, Alvarez C, Stoy M, Juchum J, Davies RM, Baxley R, Pharm. Res., 12, 1003 (1995)

[4] Baloglu E, Kingston DG, J. Nat. Prod., 62, 1068 (1999)

[5] Georgiev MI, Weber J, Maciuk A, Appl. Microbiol. Biotechnol., 83(5), 809 (2009)

[6] Ghassempour A, Rezadoost H, Mashouf A, Aboul-Enein HY, Spengler B, Rompp A, Chromatographia, 72, 833 (2010)

[7] Pyo SH, Song BK, Ju CH, Han BH, Choi HJ, Process Biochem., 40, 1113 (2005)

[8] Kim JH, Kang IS, Choi HK, Hong SS, Lee HS, Process Biochem., 37, 679 (2002)

[9] Rao KV, US Patent No. 5,670,673 (1997)

[10] Castor TP, US Patent No. 5,750,709 (1998)

[11] ElSohly HN, Croom EM, ElSohly MA, McChesney JD, US Patent No. 5,618,538 (1997)

[12] Jeon KY, Kim JH, Process Biochem., 44, 736 (2009)

[13] Lee JY, Kim JH, Sep. Purif. Technol., 80(2), 240 (2011)

[14] Pyo SH, Park HB, Song BK, Han BH, Kim JH, Process Biochem., 39, 1985 (2004)

[15] Oh HJ, Jang HR, Jung KY, Kim JH, Process Biochem., 47, 331 (2012)

[16] Han MG, Jeon KY, Mun S, Kim JH, Process Biochem., 45, 1368 (2010)

[17] Sim HA, Lee JY, Kim JH, Sep. Purif. Technol., 89, 112 (2012)

[18] Kim GJ, Park GY, Kim JH, Korean J. Microbiol. Biotechnol., 41, 272 (2013)

[19] Gamborg OL, Miller RA, Ojima K, Exp. Cell Res., 50, 151 (1968)

[20] Choi HK, Adams TL, Stahlhut RW, Kim SI, Yun JH, Song BK, Kim JH, Hong SS, Lee HS, US Patent No. 5,871,979

[21] Gregg SJ, Sing KSW, Adsorption, Surface Area and Porosity, 2nd ed., Academic Press, New York (1982)

[22] Lee JY, Kim JH, Sep. Purif. Technol., 103, 8 (2013)

[23] Kim JH, Hong SS, Korean J. Biotechnol. Bioeng., 15, 366 (2000)

[24] Hu X, Hanaoka T, Sakanishi K, Shinagawa T, Matsui S, Tada M, Iwasaki T, J. Japan Inst. Energy, 86, 707 (2007)