Confined crystallization of drug in directionally freeze-dried water-soluble template

Hyeseung Lee; Jonghwi Lee

Journal of Industrial and Engineering Chemistry, Vol.21, 1183-1190, January, 2015

DOI10.1016/j.jiec.2014.05.032 Export Citation

Confined crystallization of drug in directionally freeze-dried water-soluble template

Hyeseung Lee, and Jonghwi Lee^†

Department of Chemical Engineering and Materials Science, Chung-Ang University, 221 HeukSeok-Dong, DongJak-gu, Seoul 156-756, South Korea

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The applicability of confined crystallization is limited by the use of extra template materials unsuitable for oral dosage forms. In consideration of this limitation, mannitol was processed into a template with well controlled pores. This template was used for the subsequent confined crystallization of a model drug, resulting in drug/mannitol composite powders processable into the common operations of oral solid dosage forms. The confined crystallization produced a significantmelting point depression, caused by a significant particle size reduction, but did not alter the crystal polymorphism. The in vitro release of drug was significantly improved by the confined crystallization.

Keywords:Controlled release;Crystal engineering;Crystallization;Nanoparticles;Oral drug delivery

[References]

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Chung NO, Lee MK, Lee J, Int. J. Pharm., 437, 42 (2012)
Vehring R, Pharm. Res., 25, 999 (2008)
Junghanns JUAH, Muller RH, Int. J. Nanomed., 3, 295 (2008)
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Van Eerdenbrugh B, Van den Mooter G, Augustijns P, Int. J. Pharm., 364, 64 (2008)
Lee J, Cheng Y, J. Control. Release, 111, 185 (2006)
Matteucci ME, Hotze MA, Johnston KP, Williams RO, Langmuir, 22(21), 8951 (2006)
Eerikainen H, Watanabe W, Kauppinen EI, Ahonen P, Eur. J. Pharm. Biopharm., 55, 357 (2003)
Lee J, Lee SJ, Choi JY, Yoo JY, Ahn CH, Eur. J. Pharm. Sci., 24, 441 (2005)
Chiou H, Chan HK, Prud’homme RK, Raper JA, Drug Dev. Ind. Pharm., 34, 59 (2008)
Schwarz C, Mehnert W, Int. J. Pharm., 157, 171 (1997)
Abdelwahed W, Degobert G, Stainmesse S, Fessi H, Adv. Drug Deliv. Rev., 58, 1688 (2006)
Lee MK, Kim MY, Kim S, Lee J, J. Pharm. Sci., 98, 4808 (2009)
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Ha JM, Wolf JH, Hillmyer MA, Ward MD, J. Am. Chem. Soc., 126(11), 3382 (2004)
Lee MK, Bang J, Shin K, Lee J, Cryst. Growth Des., 10, 5187 (2010)
Beiner M, Rengarajan GT, Pankaj S, Enke D, Steinhart M, Nano Lett., 7, 1381 (2007)
Kim BS, Lee J, J. Cryst. Growth, 373, 45 (2012)
Lee MK, Chung NO, Lee J, Polymer, 51(26), 6258 (2010)
Davidson RS, Kehoe G, United States Patents, 2006/0210610 A1, 2006.
Rohatgi PK, Adams CM, Trans. Metall. Soc. AIME, 239, 1729 (1967)
Zhang H, Cooper AI, Adv. Mater., 19(11), 1529 (2007)
Deville S, Saiz E, Nalla RK, Tomsia AP, Science, 311, 515 (2006)
Forgue SR, Phillips DL, Bedding AW, Payne CD, Jewell H, Patterson BE, Wrishko RE, Mitchell MI, Br. J. Clin. Pharm., 63, 24 (2007)
Shakya AK, Abu-Awwad ANA, Arafat TA, Melhim M, J. Chromatogr. B, 852, 403 (2007)
Zhang GGZ, Law D, Schmitt EA, Qiu Y, Adv. Drug Deliv. Rev., 56, 371 (2004)
Jackson CL, McKenna GB, Chem. Mater., 8, 2128 (1996)
Ha JM, Hillmyer MA, Ward MD, J. Phys. Chem. B, 109, 1392 (2005)
Song RQ, Colfen H, Adv. Mater., 22(12), 1301 (2010)
Kajjari PB, Manjeshwar LS, Aminabhavi TM, J. Ind. Eng. Chem., 20(2), 397 (2014)
Seo HJ, Cha HJ, Kim TS, Kim JC, J. Ind. Eng. Chem., 19(1), 310 (2013)
Lee JY, Kim YS, J. Ind. Eng. Chem., 19(3), 938 (2013)
Kwon KC, Choi KS, Kim SY, Adv. Funct. Mater., 22(22), 4724 (2012)
Kim NH, Kim BJ, Ko Y, Cho JH, Chang ST, Adv. Mater., 25(6), 894 (2013)
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Im H, Kim J, Carbon, 50, 5429 (2012)

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