Mechanical behavior and in vivo properties of newly designed bare metal stent for enhanced flexibility

In-Ho Bae; Kyung-Seob Lim; Jun-Kyu Park; Dae-Sung Park; So-Youn Lee; Eun-Jae Jang; Mi Seon Ji; Doo Sun Sim; Young Joon Hong; Youngkeun Ahn; Jong Chun Park; Jeong Gwan Cho; Jung Chaee Kang; In-Su Kim; Jae-Woon Nah; Myung-Ho Jeong

Journal of Industrial and Engineering Chemistry, Vol.21, 1295-1300, January, 2015

DOI10.1016/j.jiec.2014.05.045 Export Citation

Mechanical behavior and in vivo properties of newly designed bare metal stent for enhanced flexibility

In-Ho Bae^{1, 2}, Kyung-Seob Lim¹, Jun-Kyu Park³, Dae-Sung Park^{1, 2}, So-Youn Lee^{1, 2}, Eun-Jae Jang^{1, 2}, Mi Seon Ji¹, Doo Sun Sim^{1, 4}, Young Joon Hong^{1, 4}, Youngkeun Ahn^{1, 4}, Jong Chun Park⁴, Jeong Gwan Cho⁴, Jung Chaee Kang⁴, In-Su Kim⁴, Jae-Woon Nah³, and Myung-Ho Jeong^{1, 5, †}

¹The Cardiovascular Convergence Research Center, Chonnam National University Hospital Designated by Ministry of Health and Welfare, Gwangju 501-757, Republic of Korea
²Korea Cardiovascular Stent Research Institute, Jangsung 501-893, Republic of Korea
³Department of Polymer Science and Engineering, Sunchon National University, Suncheon 540-950, Republic of Korea
⁴Department of Cardiology, Chonnam National University Hospital, Gwangju 501-757, Republic of Korea
⁵Department of Cardiology, Korea Cardiovascular Stent Research Institute, Chonnam National University Hospital, Jangsung 501-893, Republic of Korea, Gwangju 501-757, Republic of Korea

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In this study, our own stent designed by Chonnam National University Hospital (designated as CNUH stent) which is considered an elastic behavior as second trial was subjected to mechanical performance tests and in vivo histological analysis. Four commercialized stents (PROMUS ElementTM, Cypher1, Resolute Integrity, Xience PRIME) stents were employed as control. In the flat plate and compression test for measuring radial force, the lowest (2.40 ± 0.27 N) and moderate (31.27 ± 4.84 N) performance was shown in CNUH stent compared to others. On the other hand, In the 3-point bending test for measuring flexibility, CNUH stent showed the greatest flexibility (0.46 ± 0.08 N) among competitors (range between 0.66 ± 0.03 in Cypher® and 1.14 ± 0.04 Resolute Integrity), In both foreshortening and recoil test, CNUH stent showed reasonable result (2.13 ± 0.15% and 3.29 ± 0.41%, respectively). However, histological analysis showed that CNUH stent has any significant difference to Coroflex® Blue BMS on various parameters. Although the radial force of CNUH stent was slightly lower than that of other products, it showed the greatest performance in its flexibility. It can be utilized for developing drug-eluting stent as a basic structure.

Keywords:Stent design;Coronary stent;Mechanical properties;Animal study;Flexibility

[References]

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Edelman ER, Rogers C, Am. J. Cardiol., 81, 4E (1998)
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Timmins LH, Miller MW, Clubb FJ, Moore JE, Lab. Invest., 91, 955 (2011)
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Colombo A, Stankovic G, Moses JW, J. Am. Coll. Cardiol., 40, 1021 (2002)
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Li N, Zhang H, Ouyang H, Finite Elem. Anal. Des., 45, 468 (2009)
Tesfamariam B, Toxicol. Lett., 168, 93 (2007)
Rodriguez AE, Santaera O, Larribau M, Fernandez M, Sarmiento R, Perez B, Newell JB, Roubin GS, Palacios IF, Circulation, 91, 1397 (1995)
Tanimoto S, Bruining N, van Domburg RT, Rotger D, Radeva P, Ligthart JM, Serruys PW, J. Am. Coll. Cardiol., 52, 1616 (2008)
Meng S, Liu Z, Shen L, Guo Z, Chou LL, Zhong W, Du Q, Ge J, Biomaterials, 30, 2276 (2009)
Simon C, Palmaz JC, Sprague EA, J. Long.TermEff. Med. Implants, 10, 143 (2000)
Pache J, Kastrati A, Mehilli J, Schuhlen H, Dotzer F, Hausleiter J, Fleckenstein M, Neumann FJ, Sattelberger U, Schmitt C, Muller M, Dirschinger J, Schomig A, J. Am. Coll. Cardiol., 41, 1283 (2003)

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[3] Mortier P, Van Loo D, De Beule M, Segers P, Taeymans Y, Verdonck P, Verhegghe B, EuroIntervention, 4, 391 (2008)

[4] Timmins LH, Miller MW, Clubb FJ, Moore JE, Lab. Invest., 91, 955 (2011)

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[9] Morton AC, Crossman D, Gunn J, Pathol. Biol., 52, 196 (2004)

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[13] Rogers C, Tseng DY, Squire JC, Edelman ER, Circ. Res., 84, 378 (1999)

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[16] Holzapfel GA, Stadler M, Gasser TC, J. Biomech. Eng., 127, 166 (2005)

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[18] Lemos PA, Moulin B, Perin MA, Oliveira LA, Arruda JA, Lima VC, Lima AA, Caramori PR, Medeiros CR, Barbosa MR, Brito FS, Ribeiro EE, Martinez EE, Catheter. Cardiovasc. Interv., 74, 665 (2009)

[19] Lim KS, Bae IH, Kim JH, Park DS, Kim JM, Sim DS, Hong YJ, Jeong MH, Chonnam Med. J., 49, 7 (2013)

[20] Schwartz RS, Huber KC, Murphy JG, Edwards WD, Camrud AR, Vlietstra RE, Holmes DR, J. Am. Coll. Cardiol., 19, 267 (1992)

[21] Schwartz RS, Edelman E, Virmani R, Carter A, Granada JF, Kaluza GL, Chronos NA, Robinson KA, Waksman R, Weinberger J, Wilson GJ, Wilensky RL, Circ. Cardiovasc. Interv., 1, 143 (2008)

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[27] Colombo A, Stankovic G, Moses JW, J. Am. Coll. Cardiol., 40, 1021 (2002)

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[38] Simon C, Palmaz JC, Sprague EA, J. Long.TermEff. Med. Implants, 10, 143 (2000)

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