Understanding asphaltene nanoaggregation kinetics is a key to predicting the deposition in pure quartz-grain porous media. High-throughput quartz packed-bed microreactors (PBRs) were, therefore, designed to provide mechanistic insights by merging oilfield chemistry and microchemical systems. In-line UV-Vis spectroscopy and pressure transducer were used to characterize the stable packing of quartz particles with porosity of approximate to 40% and permeability of approximate to 5.5 x 10(-13) m(2). Temperature (25.0-90.0 degrees C), n-heptane composition (50.0-80.0 vol %), and n-alkane (n-C-5 to n-C-9) were all observed to influence asphaltenes deposition in the porous media, and reduced dispersion was obtained in the damaged packed-bed by estimating dispersion coefficients and the Bodenstein number. Deposition by mechanical entrapment dominated the mechanism in all scenarios, as discovered by the simplified Kozeny-Carman and Civan's permeability-porosity relationships. The results could aid in the design of remediations that minimize production losses of considerable economic magnitude. (c) 2014 American Institute of Chemical Engineers AIChE J, 60: 3534-3546, 2014