This paper addresses the problem of feedback control design for a class of linear cascaded ordinary differential equation (ODE)-partial differential equation (PDE) systems via a boundary interconnection, where the ODE system is linear time-invariant and the PDE system is described by an Euler-Bernoulli beam (EBB) equation with variable coefficients. The objective of this paper is to design a static output feedback (SOF) controller via EBB boundary and ODE measurements such that the resulting closed-loop cascaded system is exponentially stable. The Lyapunov's direct method is employed to derive the stabilization condition for the cascaded ODE-beam system, which is provided in terms of a set of bilinear matrix inequalities (BMIs). Furthermore, in order to compute the gain matrices of SOF controllers, a two-step procedure is presented to solve the BMI feasibility problem via the existing linear matrix inequality (LMI) optimization techniques. Finally, the numerical simulation is given to illustrate the effectiveness of the proposed design method. (C) 2014 Elsevier Ltd. All rights reserved.