Numerical simulation was carried out for a centrifugal short-path distillation arrangement using the computational fluid dynamics technology. Both two phases and interfacial transport were taken into account with an attempt to explore the heat and mass transport in the film body and the interface. The model tried to provide a general method to study the short-path distillation in various situations. The effects of feed flow rates, feed and heating wall temperature controlling the development of the temperature and concentration along the axial and radial direction were investigated. On the basis of the simulation results, detailed characteristics such as distribution of temperature and concentration, heat and mass transfer coefficient throughout the liquid film can be described.