A new promising additive to motor fuels is 2,3-dimethylfuran, which is distinguished by high calorific value and low hygroscopicity. 2,5-Dimethylfuran is obtained from 5-hydroxymethylfurfuraldehyde, which in turn can be obtained by hydrolysis or isomerization of fructose or other carbohydrates. In this work, we study the synthesis of 5-hydroxymethylfurfuraldehyde from fructose in different aqueous-organic media with acid catalysis. Using a mixture of 2-propanol and water resulted in a 69.9% yield of 5-hydroxymethylfurfuraldehyde.