Ignition properties of simulated syngas mixtures were systematically investigated at high-pressure low-temperature conditions relevant to gas turbine combustor operation using the University of Michigan Rapid Compression Facility. Pressure time history measurements and high-speed imaging of the ignition process in this facility were used to determine auto-ignition delay times and observe and characterize ignition behaviors. The simulated syngas mixtures were composed of H-2 and CO with a molar ratio of 0.7, for equivalence ratios (phi) of 0.1 and 0.5, near air dilution (i.e. molar O-2 to inert gas ratio of 1:3.76), with N-2 as the primary diluent gas. The pressures and temperatures after compression ranged from 3-15 atm and 870-1150 K respectively. The comprehensive results of the present work combined with those from previous shocktube studies in the literature clearly illustrate the existence of both homogeneous and inhomogeneous auto-ignition behaviors at these conditions. Analysis of patterns in the ignition behaviors revealed a dependence on temperature, pressure, and equivalence ratio with distinct thermodynamic regions in which the ignition behavior is consistent and repeatable. Predicted locations of the strong ignition limit made using a criterion which compares laminar flame speed to a thermal gradient driven front propagation speed have excellent agreement with the experimental findings for each phi and an assumed gradient of 5 K/mm. Experimental validation of this unique and powerful criterion means that it can be used for a priori prediction of the strong ignition limit using basic computational simulations. The validity of this criterion is fundamentally important, quantitatively describing the roles of chemical kinetics, thermo-physical properties, and device dependent thermal characteristics in determining auto-ignition behavior. Additionally, a comparison of the measured auto-ignition delay times to predictions made using zero-dimensional homogeneous reactor modeling revealed that agreement was dependent on phi, with excellent agreement for phi = 0.1 and large discrepancies for phi = 0.5. These results indicate that while inhomogeneous ignition phenomena are not entirely avoidable by reducing equivalence ratio, the subsequent effects on the accuracy of typical auto-ignition delay time predictions may be reduced or eliminated. (C) 2014 The Combustion Institute. Published by Elsevier Inc. All rights reserved.