The organic Rankine cycle has been one of the essential heat-work conversion technologies nowadays. Lots of effectual optimization methods are focused on the promotion of the system efficiency, which are mainly relied on engineering experience and numerical simulations rather than theoretical analysis. A theoretical integrated optimization method was established based on the entransy theory and thermodynamics, with the ratio of the net power output to the ratio of the total thermal conductance to the thermal conductance in the condenser as the objective function. The system parameters besides the optimal pinch point temperature difference were obtained. The results show that the mass flow rate of the working fluid is inversely proportional to the evaporating temperature. An optimal evaporating temperature maximizes the net power output, and the maximal net power output corresponds to the maximal entransy loss and the change points of the heat source outlet temperature and the change rates for the entropy generation and the entransy dissipation. Moreover, the net power output and the total thermal conductance are inversely proportional to the pinch point temperature difference, contradicting with each other. Under the specified condition, the optimal operating parameters are ascertained, with the optimal pinch point temperature difference of 5 K. (C) 2014 Elsevier Ltd. All rights reserved.