An experimental and modeling study of the influence of pressure on the oxidation of methyl formate (MF) has been performed in the 1-60 bar pressure range, in an isothermal tubular quartz flow reactor in the 573-1073 K temperature range. The influence of stoichiometry, temperature, pressure, and presence of NO on the conversion of MF and the formation of the main products (CH2O, CO2, CO, CH4, and H-2) has been analyzed. A detailed kinetic mechanism has been used to interpret the experimental results. The results show that the oxidation regime of MF differs significantly from atmospheric to high-pressure conditions. The impact of the NO presence has been considered, and results indicate that no net reduction of NOx is achieved, even though, at high pressure, the NO-NO2 interconversion results in a slightly increased reactivity of MF.