The main goal of this study is to analyze the potential of a multi-zone combustion modeling to simulate the homogeneous charge compression ignition (HCCI) in a process using mineral diesel fuel. The multi-zone combustion modeling consists of several volumes, named zones, that are located in fixed positions inside the combustion chamber and takes as homogeneous the composition and temperature for each volume being the pressure the same for all the zones. The start of combustion and its development were considered through specific formulations that were fitted to the model through a comparison between combustion chamber pressure measurements and model results. The model was applied to the HCCI combustion mode with both early and late injection, in the latter case with high turbulence intensity, and showed a very good capability for process simulation. The model also included the kinetics of NOx and CO formation and gave data that were close to the experimental results. (C) 2014 Elsevier Ltd. All rights reserved.