The flow of energy may be enhanced in non-linear systems, when the order is increased through export of entropy, facilitated by autocatalytic (feedback) loops. This principle has been applied to derive a far-from-equilibrium ＇self-organized＇ mechanism of electron transfer as well as a synergetic multi-electron transfer. A key requirement is the functioning of feedback loops within the macromolecules or their environment, which can transfer small amounts of energy required for self-organization. Possible macromolecular mechanisms are discussed, by which an active friction force can be exerted on electrons during transfer. A possible active role of intervening protein structure in contrast to the passive role discussed for conventional distant donor acceptor coupling is investigated. Evidence for self-organized electron transfer in photosynthetic structures is discussed. The last step in oxygen evolution is considered to be a synergetic multi-electron transfer reaction, with oscillating behavior being a consequence of it. Quasi-symmetric molecular geometries (reaction centers, manganese complex) are considered as mechanistically essential elements facilitating symmetry breaking mechanisms.