Azaribine, an antineoplastic drug of the pyrimidinic antimetabolites group, has been studied by means of polarography, cyclic voltammetry, coulometry and spectrophotometry in buffered aqueous Britton-Robinson medium at pH ranged between 2.5 and 12.0, at room temperature (25 degrees C) and ionic strength 0.1 M. Ail acid-base equilibrium involving several proton donors present in the medium precedes the electrodic process, which is an overall two-electron process where the electroactive species is the azaribine acid form (neutral molecule) and the reducible group is the C(5)=N(6) double bond.The quantitative analysis of azaribine has been carried out using DPP at the optimum basal conditions. A detection limit of 0.2 mu M corresponding to azaribine has been estimated. Quantitative determination of cytidine + azaribine mixtures is undertaken as well, since both compounds can appear together in biological samples. Tile investigation is carried out at a micromolar level and a mean error of about 2% has been detected.