Phenol methylation to 2,6-dimethylphenol was investigated in gas-phase conditions using an ironchromium catalytic fixed bed. The experiments were carried out at 603 K, at the atmospheric pressure. The long-term stability of the catalyst and the effects of the reactor packing on the phenol conversion in one- and three-section reactor were studied. It was found that, in both types of the reactor, the phenol conversion exceeded 99%. 2,6-Dimethylphenol, 2-methylphenol, and 2,4,6-trimethylphenol were identified in the outlet liquid, and methane, hydrogen, and carbon oxides were identified in the outlet gas. Selectivity to the main liquid product: 2,6-dimethylphenol of about 85% was obtained. Phenol conversion and selectivity to 2,6-dimethylphenol decreased during the process, and therefore, the regeneration of the catalyst was necessary.