In this study, the availability of ocean thermal energy conversion (OTEC) power plant has been evaluated and analyzed with condenser effluents discharge from nuclear power plant. For this, we have also calculated the performance of OTEC power system by various computer programs based on thermodynamical theories. The computer programs are developed for simulation of the closed cycle, regenerative cycle, Kalina cycle, open cycle, and hybrid cycle under equivalent conditions and various working fluids. Among these OTEC cycles, the regenerative cycle with R-134a shows the highest efficiency. It also has used the condenser effluents from the Kori, Wolsong, and Uljin nuclear power plants instead of the surface water to analyze the thermodynamic performance of the OTEC regenerative cycles. The Kori, Wolsong, and Uljin nuclear power plants have shown maximum efficiencies of 5.21%, 5.15%, and 4.83%, respectively. The net powers are 131, 93, and 192MW at the three locations, respectively. Copyright (c) 2014 John Wiley & Sons, Ltd.