TiO2 photocatalysts loaded CuS and NiS as co-catalyst were prepared by hydrothermal approach and characterized by XRD, UV-visible DRS, BET, XPS, SEM and TEM. When TiO2 was loaded MS as co-catalyst, it showed higher photocatalytic activities for splitting water into hydrogen in methanol aqueous solution under 500 W Xe lamp. Among the photocatalysts with various compositions, the maximum evolution of H-2 obtained from 5 wt% CuS-5 wt% NiS-TiO2 sample was about 800 mu mol h(-1), which was increased up to about twenty-eight times than that of TiO2 alone. It was proven that CuS, NiS can act as effective dual co-catalysts to enhance the photocatalytic H-2 production activity of TiO2. Copyright (C) 2014, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved.