A microbial fuel cell (MFC) was integrated with flat sheet membrane bioreactor (MBR) and studied for electricity generation, membrane fouling mitigation and artificial wastewater treatment. The cell potential was similar to 0.2 V with 100 Omega external load during closed circuit operation. Batch tests identified that the sludge properties and aeration in cathodic chamber were the main affecting factors on electricity generation. Integration of microbial fuel cell can significantly alleviate membrane fouling, under closed circuit condition, membrane filtration lasted 21 days - 27 days and under the open circuit condition it lasted only 13 days - 15 days, before the transmembrane pressure (TMP) reached 0.03 MPa. The calculated electrostatic repulsion force between membrane surface and membrane foulant was about 2.5 x 10(-14) N in this integrated reactor. The chemical oxygen demand (COD), ammonia nitrogen, phosphorus and offensive smell could be effectively removed by the sequential anaerobic-aerobic treatment system. The effluent pH was neutral and turbidity was very low. Copyright (C) 2014, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved.