Apparent molar volume (V2,/) and apparent molar isentropic compressibility (Ks, 2,/) of diclofenac sodium salt (DSS) drug within the concentration range of (0.001 to 0.008) mol = kg = 1 in (0.01, 0.03 and 0.05) mol = kg = 1 aqueous glycine and L-proline solutions are computed from the experimental density (q) and speed of sound (u) values at T = (293.15 to 313.15) K and atmospheric pressure. Derived parameters such as partial molar properties, transfer partial molar properties, hydration numbers and Hepler's constant are computed from the data of V2,/ and Ks, 2,/. These parameters have been used to understand the effect of temperature on interactions between DSS drug and aqueous glycine/ L-proline solution. Furthermore, the structure making and breaking ability of DSS drug in probed solutions are analysed at experimental conditions. (C) 2014 Elsevier Ltd. All rights reserved.