Pressure effects on the Raman vibrations of an energetic crystal FOX-7 (1, 1-diamino-2, 2-dinitroethene) were examined using density functional theory (DFT) calculations. High accuracy calculations were performed with a periodic plane-wave DFT method using norm-conserving pseudopotentials. Different exchange-correlation functionals were examined for their applicability in describing the structural and vibrational experimental data. It is shown that the PBE functional with an empirical dispersion correction by Grimme, PBE-D method, reproduces best the molecular geometry, unit cell parameters, and vibrational frequencies. Assignments of intramolecular Raman active vibrations are provided. The calculated pressure dependence of Raman shifts for the intramolecular and lattice modes were found to be in good agreement with the experimental data; in particular, the calculations predicted correctly a decrease of frequencies for the NH2 stretching modes with pressure. Also, in accord with experiments, the calculations indicated some instances of modes mixing/coupling with increasing pressure. This work demonstrates that the dispersion-corrected PBE functional can account for the structural and vibrational properties of FOX-7 crystal at ambient and high pressures.