Indirect iterative learning control (ILC) facilitates the application of learning-type control strategies to the repetitive/batch/periodic processes with local feedback control already. Based on the two-dimensional generalized predictive control (2D-GPC) algorithm, a new design method is proposed in this paper for an indirect ILC system which consists of a model predictive control (MPC) in the inner loop and a simple ILC in the outer loop. The major advantage of the proposed design method is realizing an integrated optimization for the parameters of existing feedback controller and design of a simple iterative learning controller, and then ensuring the optimal control performance of the whole system in sense of 2D-GPC. From the analysis of the control law, it is found that the proposed indirect ILC law can be directly obtained from a standard GPC law and the stability and convergence of the closed-loop control system can be analyzed by a simple criterion. It is an applicable and effective solution for the application of ILC scheme to the industry processes, which can be seen clearly from the numerical simulations as well as the comparisons with the other solutions. (C) 2014 Elsevier Ltd. All rights reserved.