This work aimed to estimate indications of anti-obesity and hypolipidemic effects of the extracts obtained from pink shrimp residue. The extracts were obtained by Soxhlet extraction with ethanol and by supercritical fluid extraction with carbon dioxide. The fatty acid composition and the total phenolic content of the shrimp residue extracts were determined by gas chromatography and Folin Ciocalteau methods, respectively. The anti-obesity and hypolipidemic effects were evaluated in vivo submitting the Swiss Mus musculus normal and knockout mice to a 30-day high-fat diet combined with shrimp extracts, monitoring the animals' weight, and the final cholesterol, triglycerides and glucose levels. The extracts showed high content of polyunsaturated fatty acids and significant total phenolic content. Related to the anti-obesity and hypolipidemic effects, the extracts showed good activity potential, especially the supercritical extract when applied at 50-100 mg/kg day. The considerable weight reduction observed by the extracts administration was probably not related to the absorption of the lipid components since none significant tendency of glucose reduction was detected. (C) 2014 Elsevier B.V. All rights reserved.